Cancers, Free Full-Text
Por um escritor misterioso
Descrição
Transforming growth factor-beta (TGFB) is a critical regulator of normal haematopoiesis. Dysregulation of the TGFB pathway is associated with numerous haematological malignancies including myelofibrosis, acute myeloid leukaemia, and lymphoid disorders. TGFB has classically been seen as a negative regulator of proliferation in haematopoiesis whilst stimulating differentiation and apoptosis, as required to maintain homeostasis. Tumours frequently develop intrinsic resistant mechanisms to homeostatic TGFB signalling to antagonise its tumour-suppressive functions. Furthermore, elevated levels of TGFB enhance pathogenesis through modulation of the immune system and tumour microenvironment. Here, we review recent advances in the understanding of TGFB signalling in B-cell malignancies with a focus on the tumour microenvironment. Malignant B-cells harbour subtype-specific alterations in TGFB signalling elements including downregulation of surface receptors, modulation of SMAD signalling proteins, as well as genetic and epigenetic aberrations. Microenvironmental TGFB generates a protumoural niche reprogramming stromal, natural killer (NK), and T-cells. Increasingly, evidence points to complex bi-directional cross-talk between cells of the microenvironment and malignant B-cells. A greater understanding of intercellular communication and the context-specific nature of TGFB signalling may provide further insight into disease pathogenesis and future therapeutic strategies.
8 Ways to prevent cancer & be healthy -Siteman Cancer Center
Rare Cancer Day - National Organization for Rare Disorders
Frailty and prognosis in lung cancer: systematic review and meta-analysis
Free Cancer Treatment in India: 21 Best Cancer Hospitals in India for Free Cancer Treatment, 2023
Destination Healthy Skin Toolkit - The Skin Cancer Foundation
Multimodal analysis of cell-free DNA whole-methylome sequencing for cancer detection and localization
Cancer-Free, Third Edition by Bill Henderson - Audiobook
The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 - The Lancet
USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity, Molecular Cancer
Cancer Free Posters for Sale
Cancer Free Posters for Sale
de
por adulto (o preço varia de acordo com o tamanho do grupo)
