JCM, Free Full-Text

Por um escritor misterioso

Descrição

Non-syndromic tooth agenesis (ns-TA) is one of the most common dental anomalies characterized by the congenital absence of at least one permanent tooth (excluding third molars). Regarding the essential role of genetic factors in ns-TA aetiology, the present study aimed to identify novel pathogenic variants underlying hypodontia and oligodontia. In a group of 65 ns-TA patients and 127 healthy individuals from the genetically homogenous Polish population, the coding sequences of 423 candidate genes were screened using targeted next-generation sequencing. Pathogenic and likely pathogenic variants were identified in 37 (56.92%) patients, including eight nucleotide alternations of genes not previously implicated in ns-TA (CHD7, CREBBP, EVC, LEF1, ROR2, TBX22 and TP63). However, since only single variants were detected, future research is required to confirm and fully understand their role in the aetiology of ns-TA. Additionally, our results support the importance of already known ns-TA candidate genes (AXIN2, EDA, EDAR, IRF6, LAMA3, LRP6, MSX1, PAX9 and WNT10A) and provide additional evidence that ns-TA might be an oligogenic condition involving the cumulative effect of rare variants in two or more distinct genes.
JCM, Free Full-Text
thierryhenry couldn't help but banter @23carra here. 😅 #ucltoday #uc, jamie carragher
JCM, Free Full-Text
Pizza Delivery & Carryout, Pasta, Chicken & More
JCM, Free Full-Text
Marshall JCM2000 Triple Super Lead 100 Head
JCM, Free Full-Text
Joint Base Lewis-McChord on X: JBLM FLU DRIVE Nov. 2-4; 8 a.m. – 3 p.m. - Lewis Main Exchange Nov. 6, 8 and 14; 3 – 6 p.m. - Nov. 6 –
JCM, Free Full-Text
JCM, Free Full-Text
JCM, Free Full-Text
Youth Sports & Fitness :: Joint Base Lewis-McChord :: US Army MWR
JCM, Free Full-Text
JCM 800 Zack Wylde, Kemper Profiles
JCM, Free Full-Text
WJTL FM 90.3 – Christ. Community. Music.Top 100
JCM, Free Full-Text
Download Free JCM800 simulation plugin: JessieM X100 by Vadim Taranov
JCM, Free Full-Text
Convert many RAW formats to JPGs in seconds for free!
JCM, Free Full-Text
Fet version of the JCM800
JCM, Free Full-Text
Jesus SVG, He Calls Me Friend SVG, Christian SVG
JCM, Free Full-Text
Home Krystal Restaurants
de por adulto (o preço varia de acordo com o tamanho do grupo)