Molecules, Free Full-Text

Por um escritor misterioso

Descrição

COVID-19 is an acute respiratory disease caused by SARS-CoV-2 that has spawned a worldwide pandemic. ADAM17 is a sheddase associated with the modulation of the receptor ACE2 of SARS-CoV-2. Studies have revealed that malignant phenotypes of several cancer types are closely relevant to highly expressed ADAM17. However, ADAM17 regulation in SARS-CoV-2 invasion and its role on small molecules are unclear. Here, we evaluated the ADAM17 inhibitory effects of cordycepin (CD), thymoquinone (TQ), and N6, N6-dimethyladenosine (m62A), on cancer cells and predicted the anti-COVID-19 potential of the three compounds and their underlying signaling pathways by network pharmacology. It was found that CD, TQ, and m62A repressed the ADAM17 expression upon different cancer cells remarkably. Moreover, CD inhibited GFP-positive syncytia formation significantly, suggesting its potential against SARS-CoV-2. Pharmacological analysis by constructing CD-, TQ-, and m62A-based drug-target COVID-19 networks further indicated that ADAM17 is a potential target for anti-COVID-19 therapy with these compounds, and the mechanism might be relevant to viral infection and transmembrane receptors-mediated signal transduction. These findings imply that ADAM17 is of potentially medical significance for cancer patients infected with SARS-CoV-2, which provides potential new targets and insights for developing innovative drugs against COVID-19.
Molecules, Free Full-Text
Molecule Background Stock Photo, Picture and Royalty Free Image
Molecules, Free Full-Text
Premium Photo Abstract science background with molecules full
Molecules, Free Full-Text
Chemical Formula of Common Compounds,Chemical reaction,Molecular
Molecules, Free Full-Text
Free Vector Unfocused background of molecules
Molecules, Free Full-Text
Angewandte Chemie International Edition: Early View
Molecules, Free Full-Text
Molecules An Open Access Journal from MDPI
Molecules, Free Full-Text
Molecules, Free Full-Text
Molecules, Free Full-Text
The importance of water-solid interactions in small molecule drug
Molecules, Free Full-Text
Molecules, Free Full-Text
de por adulto (o preço varia de acordo com o tamanho do grupo)